Intracellular origin and ultrastructure of platelet-derived microparticles.

ABSTRACT: Essentials Platelet microparticles play a major role in pathologies, including hemostasis and thrombosis. Platelet microparticles have been analyzed and classified based on their ultrastructure. The structure and intracellular origin of microparticles depend on the cell-activating stimulus. Thrombin-treated platelets fall apart and form microparticles that contain cellular organelles.

Summary

Background Platelet-derived microparticles comprise the major population of circulating blood microparticles that play an important role in hemostasis and thrombosis. Despite numerous studies on the (patho)physiological roles of platelet-derived microparticles, mechanisms of their formation and structural details remain largely unknown. Objectives Here we studied the formation, ultrastructure a

SUBMITTER: Ponomareva AA 

PROVIDER: S-EPMC5657319 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature