Clinical and Incidental Perineural Invasion of Cutaneous Squamous Cell Carcinoma: A Systematic Review and Pooled Analysis of Outcomes Data.

ABSTRACT:

Importance

Perineural invasion (PNI) in cutaneous squamous cell carcinoma (CSCC) has been associated with an increased risk of poor outcomes. Patients with PNI may present with clinical symptoms and/or radiologic evidence of PNI (clinical PNI [CPNI]), yet most patients are asymptomatic and PNI is often found on histologic examination (incidental PNI [IPNI]). Evidence-based estimates of the risks of disease-related outcomes comparing IPNI and CPNI are limited in the dermatology literature.

Objectives

To review and synthesize outcomes data for patients with CSCC and CPNI or IPNI.

Data sources

A systematic review was conducted in MEDLINE and EMBASE for English-language articles published since inception to November 11, 2016.

Study selection

All studies that report

SUBMITTER: Karia PS 

PROVIDER: S-EPMC5657475 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature