No histologic evidence of foetal cardiotoxicity following exposure to maternal hydroxychloroquine.

ABSTRACT: It is currently recommended that hydroxychloroquine (HCQ) be maintained during pregnancy in patients with systemic lupus erythematosus. Recent data suggest that this Toll-like receptor inhibitor may also reduce the recurrence rate of anti-SSA/Ro associated congenital heart block (CHB). This case report describes a unique situation in which a CHB-afflicted, HCQ-exposed pregnancy was electively terminated. The heart did not reveal any characteristic features of cardiotoxicity, providing further evidence supporting the safety of foetal exposure to HCQ.

SUBMITTER: Friedman D 

PROVIDER: S-EPMC5657477 | biostudies-literature | 2017 Sep-Oct

REPOSITORIES: biostudies-literature