Effects of prior influenza virus vaccination on maternal antibody responses: Implications for achieving protection in the newborns.

ABSTRACT:

Background

In the US, influenza vaccination is recommended annually to everyone ≥6months. Prior receipt of influenza vaccine can dampen antibody responses to subsequent vaccination. This may have implications for pregnant women and their newborns, groups at high risk for complications from influenza infection.

Objective

This study examined effects of prior vaccination on maternal and cord blood antibody levels in a cohort of pregnant women in the US.

Study design

Influenza antibody titers were measured in 141 pregnant women via the hemagglutination inhibition (HAI) assay prior to receipt of quadrivalent influenza vaccine, 30days post-vaccination, and at delivery (maternal and cord blood). Logistic regression analyses adjusting for age, BMI, parity, gestational age at

SUBMITTER: Christian LM 

PROVIDER: S-EPMC5657512 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature