Intermittent Access to Ethanol Induces Escalated Alcohol Consumption in Primates.

ABSTRACT:

Background

Escalation of voluntary alcohol drinking is characteristic of alcohol addiction and can be induced in rodents using intermittent access to alcohol. This model has been used to evaluate candidate therapeutics, but key systems involved in the transition into alcohol addiction, such as CRF, differ in their organization between rodents and primates. We examined the ability of an intermittent access schedule to induce escalation of voluntary alcohol drinking in non-human primates and used this model to assess the role of corticotropin releasing hormone (CRF) signaling in this process.

Methods

Four young adult male rhesus macaques were given access to an 8.4% alcohol solution every other weekday (EOD; M, W, F), while four other young adult males were given the same solu

SUBMITTER: Lindell SG 

PROVIDER: S-EPMC5658047 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature