Time to glucose peak during an oral glucose tolerance test identifies prediabetes risk.

ABSTRACT:

Context

Morphological characteristics of the glucose curve during an oral glucose tolerance test (OGTT) (time to peak and shape) may reflect different phenotypes of insulin secretion and action, but their ability to predict diabetes risk is uncertain.

Objective

To compare the ability of time to glucose peak and curve shape to detect prediabetes and β-cell function.

Design and participants

In a cross-sectional evaluation using an OGTT, 145 adults without diabetes (age 42±9 years (mean±SD), range 24-62 years, BMI 29.2±5.3 kg/m² , range 19.9-45.2 kg/m² ) were characterized by peak (30 minutes vs >30 minutes) and shape (biphasic vs monophasic).

Main outcome measures

Prediabetes and disposition index (DI)-a marker of β-cell function.

Results

SUBMITTER: Chung ST 

PROVIDER: S-EPMC5658251 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature