Ror2-mediated alternative Wnt signaling regulates cell fate and adhesion during mammary tumor progression.

ABSTRACT: Cellular heterogeneity is a common feature in breast cancer, yet an understanding of the coexistence and regulation of various tumor cell subpopulations remains a significant challenge in cancer biology. In the current study, we approached tumor cell heterogeneity from the perspective of Wnt pathway biology to address how different modes of Wnt signaling shape the behaviors of diverse cell populations within a heterogeneous tumor landscape. Using a syngeneic TP53-null mouse model of breast cancer, we identified distinctions in the topology of canonical Wnt β-catenin-dependent signaling activity and non-canonical β-catenin-independent Ror2-mediated Wnt signaling across subtypes and within tumor cell subpopulations in vivo. We further discovered an antagonistic role for Ror2 in regulating ca

SUBMITTER: Roarty K 

PROVIDER: S-EPMC5658260 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature