Bisphenol A in eggs causes development-specific liver molecular reprogramming in two generations of rainbow trout.

ABSTRACT: Bisphenol A (BPA) is widely used in the manufacture of plastics and epoxy resins and is prevalent in the aquatic environment. BPA disrupts endocrine pathways in fish, but the long-term developmental implications are unknown. We demonstrate that BPA deposition in the eggs of rainbow trout (Oncorhynchus mykiss), an ecologically and economically important species of fish, reprograms liver metabolism in the offspring and alters the developmental growth trajectory in two generations. Specifically, BPA reduces growth during early development, followed by a catch-up growth post-juveniles. More importantly, we observed a developmental shift in the liver transcriptome, including an increased propensity for protein breakdown during early life stages to lipid and cholesterol synthesis post- juveniles

SUBMITTER: Sadoul B 

PROVIDER: S-EPMC5658357 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature