Proteomic profiling of neuronal mitochondria reveals modulators of synaptic architecture.

ABSTRACT:

Background

Neurons are highly polarized cells consisting of three distinct functional domains: the cell body (and associated dendrites), the axon and the synapse. Previously, it was believed that the clinical phenotypes of neurodegenerative diseases were caused by the loss of entire neurons, however it has recently become apparent that these neuronal sub-compartments can degenerate independently, with synapses being particularly vulnerable to a broad range of stimuli. Whilst the properties governing the differential degenerative mechanisms remain unknown, mitochondria consistently appear in the literature, suggesting these somewhat promiscuous organelles may play a role in affecting synaptic stability. Synaptic and non-synaptic mitochondrial subpools are known to have different enz

SUBMITTER: Graham LC 

PROVIDER: S-EPMC5659037 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature