A randomized phase II feasibility trial of a multimodal intervention for the management of cachexia in lung and pancreatic cancer.

ABSTRACT:

Background

Cancer cachexia is a syndrome of weight loss (including muscle and fat), anorexia, and decreased physical function. It has been suggested that the optimal treatment for cachexia should be a multimodal intervention. The primary aim of this study was to examine the feasibility and safety of a multimodal intervention (n-3 polyunsaturated fatty acid nutritional supplements, exercise, and anti-inflammatory medication: celecoxib) for cancer cachexia in patients with incurable lung or pancreatic cancer, undergoing chemotherapy.

Methods

Patients receiving two cycles of standard chemotherapy were randomized to either the multimodal cachexia intervention or standard care. Primary outcome measures were feasibility assessed by recruitment, attrition, and compliance with inter

SUBMITTER: Solheim TS 

PROVIDER: S-EPMC5659068 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature