Auditory training changes temporal lobe connectivity in 'Wernicke's aphasia': a randomised trial.

ABSTRACT:

Introduction

Aphasia is one of the most disabling sequelae after stroke, occurring in 25%-40% of stroke survivors. However, there remains a lack of good evidence for the efficacy or mechanisms of speech comprehension rehabilitation.

Trial design

This within-subjects trial tested two concurrent interventions in 20 patients with chronic aphasia with speech comprehension impairment following left hemisphere stroke: (1) phonological training using 'Earobics' software and (2) a pharmacological intervention using donepezil, an acetylcholinesterase inhibitor. Donepezil was tested in a double-blind, placebo-controlled, cross-over design using block randomisation with bias minimisation.

Methods

The primary outcome measure was speech comprehension score on the comprehensive aph

SUBMITTER: Woodhead ZV 

PROVIDER: S-EPMC5659142 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature