Neoadjuvant systemic therapy in breast cancer: use and trends in radiotherapy practice.

ABSTRACT:

Background

The use of neoadjuvant systemic therapy (nast) in the treatment of breast cancer is increasing, and the role of adjuvant radiation therapy (rt) in that setting is uncertain. We sought to review and report the use of nast, its trends over time, and its relationship with the prescribing patterns of locoregional rt in a provincial cancer system.

Methods

Patients with stages i-iii breast cancer diagnosed during 2007-2012 were identified using a provincial database. Patient, tumour, and treatment characteristics were extracted. Multivariable logistic regression analyses were used to assess associations with the use of nast. Kaplan-Meier and Cox regression were used for survival analyses.

Results

Of the 11,658 patients who met the inclusion criteria, 602 (5%) had

SUBMITTER: Koulis TA 

PROVIDER: S-EPMC5659152 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature