Association of TNF-alpha G-308A gene polymorphism with depression: a meta-analysis.

ABSTRACT:

Background

Although many studies have investigated the association of a single nucleotide polymorphism in TNF-α G-308A gene with depression, their association is still controversial. To clarify this, we performed a meta-analysis.

Method

Studies related to TNF-α G-308A and depression were retrieved from PubMed, Medline, Embase, and Scopus (up to April 18, 2017). The odds ratios (ORs) and 95% confidence intervals (CIs) were estimated in the models of allele comparison (G vs A), homozygote comparison (GG vs AA), dominant (GG vs GA + AA), and recessive (GG + GA vs AA) to estimate the strength of the associations.

Results

A total of 10 case-control studies were included in this meta-analysis. Overall, no significant association between TNF-α G-308A and depression was found

SUBMITTER: Shin KH 

PROVIDER: S-EPMC5659227 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature