Inferior Olivary TMEM16B Mediates Cerebellar Motor Learning.

ABSTRACT: Ca²⁺-activated ion channels shape membrane excitability and Ca²⁺ dynamics in response to cytoplasmic Ca²⁺ elevation. Compared to the Ca²⁺-activated K⁺ channels, known as BK and SK channels, the physiological importance of Ca²⁺-activated Cl^- channels (CaCCs) in neurons has been largely overlooked. Here we report that CaCCs coexist with BK and SK channels in inferior olivary (IO) neurons that send climbing fibers to innervate cerebellar Purkinje cells for the control of motor learning and timing. Ca²⁺ influx through the dendritic high-threshold voltage-gated Ca²⁺ channels activates CaCCs, which contribute to membrane repolarization of IO neurons. Loss of TMEM16B expression resulted in the absen

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC5659299 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature