Normobaric Hyperoxia Reduces Blood Occludin Fragments in Rats and Patients With Acute Ischemic Stroke.

ABSTRACT:

Background and purpose

Damage of the blood-brain barrier (BBB) increases the incidence of neurovascular complications, especially for cerebral hemorrhage after tPA (tissue-type plasminogen activator) therapy. Currently, there is no effective method to evaluate the extent of BBB damage to guide tPA use. Herein, we investigated whether blood levels of tight junction proteins could serve as biomarker of BBB damages in acute ischemic stroke (AIS) in both rats and patients. We examined whether this biomarker could reflect the extent of BBB permeability during cerebral ischemia/reperfusion and the effects of normobaric hyperoxia (NBO) on BBB damage.

Methods

Rats were exposed to NBO (100% O₂) or normoxia (21% O₂) during middle cerebral artery occlusion. BBB pe

SUBMITTER: Shi S 

PROVIDER: S-EPMC5659343 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature