Prostate specific membrane antigen (PSMA) expression in non-small cell lung cancer.

ABSTRACT:

Objectives

PSMA (prostate-specific membrane antigen) is overexpressed in prostate cancer cells and is reported to be a promising target for antibody-based radioligand therapy in patients with metastasized prostate cancer. Since PSMA expression is not restricted to prostate cancer, the underlying study investigates PSMA expression in non-small cell lung cancer (NSCLC).

Material and methods

Immunohistochemistry was used to identify PSMA expression in n = 275 samples of NSCLC tissue specimens. By means of CD34 co-expression, the level of PSMA expression in tumor associated neovasculature was investigated. The impact of PSMA expression on clinicopathologic parameters and prognosis was evaluated.

Results

PSMA tumor cell expression in NSCLC is as low as 6% and was predomina

SUBMITTER: Schmidt LH 

PROVIDER: S-EPMC5659610 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature