A novel controller based on state-transition models for closed-loop vagus nerve stimulation: Application to heart rate regulation.

ABSTRACT: Vagus nerve stimulation (VNS) is an established adjunctive therapy for pharmacologically refractory epilepsy and depression and is currently in active clinical research for other applications. In current clinical studies, VNS is delivered in an open-loop approach, where VNS parameters are defined during a manual titration phase. However, the physiological response to a given VNS configuration shows significant inter and intra-patient variability and may significantly evolve through time. VNS closed-loop approaches, allowing for the optimization of the therapy in an adaptive manner, may be necessary to improve efficacy while reducing side effects. This paper proposes a generic, closed-loop control VNS system that is able to optimize a number of VNS parameters in an adaptive fashion, in orde

SUBMITTER: Romero-Ugalde HM 

PROVIDER: S-EPMC5659642 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature