Cardiovascular risk factors as determinants of retinal and skin microvascular function: The Maastricht Study.

ABSTRACT:

Objective

Microvascular dysfunction is an important underlying mechanism of microvascular diseases. Determinants (age, sex, hypertension, dyslipidemia, hyperglycemia, obesity, and smoking) of macrovascular diseases affect large-artery endothelial function. These risk factors also associate with microvascular diseases. We hypothesized that they are also determinants of microvascular (endothelial) function.

Methods

In The Maastricht Study, a type 2 diabetes-enriched population-based cohort study (n = 1991, 51% men, aged 59.7±8.2 years), we determined microvascular function as flicker light-induced retinal arteriolar %-dilation and heat-induced skin %-hyperemia. Multiple linear regression analyses were used to assess the associations of cardiovascular risk factors (age, sex, wa

SUBMITTER: Sorensen BM 

PROVIDER: S-EPMC5659678 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature