DNA methylation and gene expression of TXNIP in adult offspring of women with diabetes in pregnancy.

ABSTRACT:

Background

Fetal exposure to maternal diabetes increases the risk of type 2 diabetes (T2DM), possibly mediated by epigenetic mechanisms. Low blood TXNIP DNA methylation has been associated with elevated glucose levels and risk of T2DM, and increased skeletal muscle TXNIP gene expression was reported in subjects with impaired glucose metabolism or T2DM. Subcutaneous adipose tissue (SAT) and skeletal muscle play a key role in the control of whole body glucose metabolism and insulin action. The extent to which TXNIP DNA methylation levels are decreased and/or gene expression levels increased in SAT or skeletal muscle of a developmentally programmed at-risk population is unknown.

Objective and methods

The objective of this study was to investigate TXNIP DNA methylation and gene

SUBMITTER: Houshmand-Oeregaard A 

PROVIDER: S-EPMC5659766 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature