Biological substantiation of antipsychotic-associated pneumonia: Systematic literature review and computational analyses.

ABSTRACT:

Introduction

Antipsychotic (AP) safety has been widely investigated. However, mechanisms underlying AP-associated pneumonia are not well-defined.

Aim

The aim of this study was to investigate the known mechanisms of AP-associated pneumonia through a systematic literature review, confirm these mechanisms using an independent data source on drug targets and attempt to identify novel AP drug targets potentially linked to pneumonia.

Methods

A search was conducted in Medline and Web of Science to identify studies exploring the association between pneumonia and antipsychotic use, from which information on hypothesized mechanism of action was extracted. All studies had to be in English and had to concern AP use as an intervention in persons of any age and for any indication,

SUBMITTER: Sultana J 

PROVIDER: S-EPMC5659779 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature