Deep Brain Stimulation Influences Brain Structure in Alzheimer's Disease.

ABSTRACT:

Background

Deep Brain Stimulation (DBS) is thought to improve the symptoms of selected neurological disorders by modulating activity within dysfunctional brain circuits. To date, there is no evidence that DBS counteracts progressive neurodegeneration in any particular disorder.

Objective/hypothesis

We hypothesized that DBS applied to the fornix in patients with Alzheimer's Disease (AD) could have an effect on brain structure.

Methods

In six AD patients receiving fornix DBS, we used structural MRI to assess one-year change in hippocampal, fornix, and mammillary body volume. We also used deformation-based morphometry to identify whole-brain structural changes. We correlated volumetric changes to hippocampal glucose metabolism. We also compared volumetric changes to thos

SUBMITTER: Sankar T 

PROVIDER: S-EPMC5659851 | biostudies-literature | 2015 May-Jun

REPOSITORIES: biostudies-literature