Progesterone for smoking relapse prevention following delivery: A pilot, randomized, double-blind study.

ABSTRACT:

Introduction

Close to half of women who were smokers prior to conception quit smoking in pregnancy, when endogenous progesterone levels are high. However, at least half resume pre-pregnancy smoking levels within weeks after delivery and when progesterone levels drop. The current pilot study tested the feasibility and preliminary efficacy of postpartum progesterone replacement in preventing relapse to smoking in postpartum women with a history of pre-pregnancy smoking.

Methods

This was an 8-week, double-blind, parallel, randomized, placebo-controlled pilot trial of 41 women with a history of pre-pregnancy smoking who achieved abstinence by 32 weeks of gestation. Immediately following delivery women were randomized to oral micronized progesterone (200mg twice daily) or placebo

SUBMITTER: Forray A 

PROVIDER: S-EPMC5659923 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature