Inhibition of microsomal PGE synthase-1 reduces human vascular tone by increasing PGI₂ : a safer alternative to COX-2 inhibition.

ABSTRACT:

Background and purpose

The side effects of cyclooxygenase-2 (COX-2) inhibitors on the cardiovascular system could be associated with reduced prostaglandin (PG)I₂ synthesis. Microsomal PGE synthase-1 (mPGES-1) catalyses the formation of PGE₂ from COX-derived PGH₂ . This enzyme is induced under inflammatory conditions and constitutes an attractive target for novel anti-inflammatory drugs. However, it is not known whether mPGES-1 inhibitors could be devoid of cardiovascular side effects. The aim of this study was to compare, in vitro, the effects of mPGES-1 and COX-2 inhibitors on vascular tone in human blood vessels.

Experimental approach

The vascular tone and prostanoid release from internal mammary artery (IMA) and saphenous vein (SV) incubat

SUBMITTER: Ozen G 

PROVIDER: S-EPMC5660006 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature