IL-36α Regulates Tubulointerstitial Inflammation in the Mouse Kidney.

ABSTRACT: IL-36α, a member of the IL-1 family, is a crucial mediator of inflammatory responses. We previously found that IL-36α was overexpressed in injured distal tubules (DTs); however, its pathological function remains unclear. Herein, unilateral ureter obstruction (UUO) or folic acid (FA) injection was performed in mouse kidneys to assess the role of IL-36α in kidney injury. IL-36α mRNA and protein expression significantly increased in the kidneys within 24 h after UUO. IL-36α localized to dilated DTs. IL-36α expression significantly correlated with the progression of tubulointerstitial cell infiltration and tubular epithelium cell death in UUO kidneys and with renal dysfunction in FA-induced acute kidney injury mice. At 24 h after UUO, IL-36α⁺ DT epithelial cells showed loose interce

SUBMITTER: Ichii O 

PROVIDER: S-EPMC5660075 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature