Genomic Comparisons Reveal Microevolutionary Differences in Mycobacterium abscessus Subspecies.

ABSTRACT: Mycobacterium abscessus, a rapid-growing non-tuberculous mycobacterium, has been the cause of sporadic and outbreak infections world-wide. The subspecies in M. abscessus complex (M. abscessus, M. massiliense, and M. bolletii) are associated with different biologic and pathogenic characteristics and are known to be among the most frequently isolated opportunistic pathogens from clinical material. To date, the evolutionary forces that could have contributed to these biological and clinical differences are still unclear. We compared genome data from 243 M. abscessus strains downloaded from the NCBI ftp Refseq database to understand how the microevolutionary processes of homologous recombination and positive selection influenced the diversification of the M. abscessus complex at the subspecies

SUBMITTER: Tan JL 

PROVIDER: S-EPMC5660101 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature