Genetic and phenotypic characterization of the novel mouse substrain C57BL/6N Korl with increased body weight.

ABSTRACT: In inbred mouse lines, there is generally little genetic difference between individuals. This small genetic variability facilitates carrying out research on minute changes of various traits and the gene pool. Also, characterizing the diversity and detecting selective genetic and phenotypic signatures are crucial to understanding the genomic basis of a population and to identify specific patterns of evolutionary change. In this study, we investigated the underlying genetic profiles of a newly developed mouse strain, C57BL/6NKorl (Korl), established through sibling mating over 30 generations. To analyse the distinctive genomic features of Korl mice, we used whole-genome sequencing from six samples, which were compared to those of other C57BL/6N-based mouse strains. Korl strain-specific polym

SUBMITTER: Choi KM 

PROVIDER: S-EPMC5660189 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature