Complementary mechanisms for neurotoxin resistance in a copepod.

ABSTRACT: Toxin resistance is a recurring evolutionary response by predators feeding on toxic prey. These adaptations impact physiological interaction and community ecology. Mechanisms for resistance vary depending on the predator and the nature of the toxin. Potent neurotoxins like tetrodotoxin (TTX) and saxitoxin (STX) that are highly toxic to humans and other vertebrates, target conserved voltage-gated sodium channels (Na_V) of nerve and muscle, causing paralysis. The copepod Calanus finmarchicus consumes the STX-producing dinoflagellate, Alexandrium fundyense with no effect on survival. Using transcriptomic approaches to search for the mechanism that confers resistance in C. finmarchicus, we identified splice variants of Na_Vs that were predicted to be toxin resistant. These

SUBMITTER: Roncalli V 

PROVIDER: S-EPMC5660226 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature