An intrinsically disordered linker controlling the formation and the stability of the bacterial flagellar hook.

ABSTRACT:

Background

In a macro-molecular complex, any minor change may prove detrimental. For a supra-molecular nano-machine like the bacterial flagellum, which consists of several distinct parts with specific characteristics, stability is important. During the rotation of the bacterial flagellar motor, which is located in the membrane, the flagella rotate at speeds between 200 and 2000 rpm, depending on the bacterial species. The hook substructure of the bacterial flagellum acts as a universal joint connecting the motor to the flagellar filament. We investigated the formation of the bacterial flagellar hook and its overall stability between the FlgE subunits that make up the hook and attempted to understand how this stability differs between bacteria.

Results

An intrinsically disord

SUBMITTER: Barker CS 

PROVIDER: S-EPMC5660449 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature