A Compendium of Co-regulated Protein Complexes in Breast Cancer Reveals Collateral Loss Events.

ABSTRACT: Protein complexes are responsible for the bulk of activities within the cell, but how their behavior and abundance varies across tumors remains poorly understood. By combining proteomic profiles of breast tumors with a large-scale protein-protein interaction network, we have identified a set of 285 high-confidence protein complexes whose subunits have highly correlated protein abundance across tumor samples. We used this set to identify complexes that are reproducibly under- or overexpressed in specific breast cancer subtypes. We found that mutation or deletion of one subunit of a co-regulated complex was often associated with a collateral reduction in protein expression of additional complex members. This collateral loss phenomenon was typically evident from proteomic, but not transcripto

SUBMITTER: Ryan CJ 

PROVIDER: S-EPMC5660599 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature