SIgA, TGF-β1, IL-10, and TNFα in Colostrum Are Associated with Infant Group B Streptococcus Colonization.

ABSTRACT:

Background

Group B Streptococcus (GBS) is a major cause of mortality and morbidity in infants and is associated with transmission from a colonized mother at birth and via infected breastmilk. Although maternal/infant colonization with GBS is common, the majority of infants exposed to GBS remain unaffected. The association between breastmilk immune factors and infant colonization and disease prevention has not been elucidated.

Objectives

We have investigated the association between SIgA and cytokines in breastmilk and infant GBS colonization and clearance.

Methods

Mother/infant GBS colonization was determined in a prospective cohort of 750 Gambian mother/infant pairs followed to day 89 of life. Anti-GBS secretory IgA bound to the surface of whole bacteria

SUBMITTER: Le Doare K 

PROVIDER: S-EPMC5660603 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature