The relationship of blood glucose with cardiovascular disease is mediated over time by traditional risk factors in type 1 diabetes: the DCCT/EDIC study.

ABSTRACT:

Aims/hypothesis

Chronic hyperglycaemia, as measured by HbA_1c levels, is a major risk factor for atherosclerosis and cardiovascular disease (CVD) in type 1 diabetes. Our aim was to describe the degree to which the effect of HbA_1c on the risk of CVD is mediated by its effect on traditional risk factors over time, and how these mediation pathways change over time.

Methods

The DCCT and its observational follow-up study, the Epidemiology of Diabetes Interventions and Complications (EDIC), followed 1441 participants for a mean of 27 years, with periodic measurement of HbA_1c and risk factors over time. We assessed the proportion of the HbA_1c effect on risk of CVD that was mediated through its effects on systolic BP (SBP), pulse rate, tria

SUBMITTER: Bebu I 

PROVIDER: S-EPMC5660661 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature