KCTD5 and Ubiquitin Proteasome Signaling Are Required for Helicobacter pylori Adherence.

ABSTRACT: In order to establish infection, bacterial pathogens modulate host cellular processes by using virulence factors, which are delivered from the bacteria to the host cell leading to cellular reprogramming. In this context, several pathogens regulate the ubiquitin proteasome system in order to regulate the cellular effectors required for their successful colonization and persistance. In this study, we investigated how Helicobacter pylori affect the ubiquitination of the host proteins to achieve the adherence to the cells, using AGS gastric epithelial cells cultured with H. pylori strains, H. pylori 26695 and two isogenic mutants H. pylori cag::cat and vacA::apha3, to characterize the ability of H. pylori to reprogram the ubiquitin proteasome systems.

SUBMITTER: Alvarez A 

PROVIDER: S-EPMC5660694 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature