Collagen VI Null Mice as a Model for Early Onset Muscle Decline in Aging.

ABSTRACT: Collagen VI is an extracellular matrix (ECM) protein playing a key role in skeletal muscles and whose deficiency leads to connective tissue diseases in humans and in animal models. However, most studies have been focused on skeletal muscle features. We performed an extensive proteomic profiling in two skeletal muscles (diaphragm and gastrocnemius) of wild-type and collagen VI null (Col6a1^-/-) mice at different ages, from 6- (adult) to 12- (aged) month-old to 24 (old) month-old. While in wild-type animals the number of proteins and the level of modification occurring during aging were comparable in the two analyzed muscles, Col6a1^-/- mice displayed a number of muscle-type specific variations. In particular, gastrocnemius displayed a limited number of dysr

SUBMITTER: Capitanio D 

PROVIDER: S-EPMC5660719 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature