Sweet taste liking is associated with subjective response to amphetamine in women but not men.

ABSTRACT:

Rationale and objective

Preference for sweet taste rewards has been linked to the propensity for drug use in both animals and humans. Here, we tested the association between sweet taste liking and sensitivity to amphetamine reward in healthy adults. We hypothesized that sweet likers would report greater euphoria and stimulation following D-amphetamine (20 mg) compared to sweet dislikers.

Methods

Men (n = 36) and women (n = 34) completed a sweet taste test in which they rated their liking of various concentrations of sucrose and filtered water (0.05, 0.10, 0.21, 0.42, and 0.83 M). Participants who preferred the highest concentration were classified as "sweet likers." All others were classified as "sweet dislikers." They then completed four sessions in which they received D-am

SUBMITTER: Weafer J 

PROVIDER: S-EPMC5660927 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature