Early life adversity influences stress response association with smoking relapse.

ABSTRACT:

Rationale

We examined the hypothesis that stress-related blunting of cortisol in smokers is particularly pronounced in those with a history of severe life adversity.

Objectives

The two aims of this study were first to examine hormonal, craving, and withdrawal symptoms during ad libitum smoking and after the first 24 h of abstinence in smokers who experienced high or low levels of adversity. Second, we sought to examine the relationship between adversity and hypothalamic-pituitary-adrenal (HPA) hormones to predict relapse during the first month of a smoking cessation attempt.

Methods

Hormonal and self-report measures were collected from 103 smokers (49 women) during ad libitum smoking and after the first 24 h of abstinence. HPA hormones were measured during baseline re

SUBMITTER: al'Absi M 

PROVIDER: S-EPMC5660945 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature