Therapeutic roles of telocytes in OVA-induced acute asthma in mice.

ABSTRACT: Telocytes (TCs) newly discovered as the mesenchyme-derived interstitial cells were found to have supportive effects on mesenchymal stem cells (MSCs). The present study aimed at investigating effects of TCs or TCs gathered with MSCs on experimental airway inflammation and hyper-responsiveness. The TCs were isolated from the lung tissue of the female BALB/c mice. The ovalbumin (OVA)-induced asthma model was established. TCs (1 × 10⁶ /2 × 10⁶ ) and/or MSCs (1 × 10⁶ ) were injected through mice tail vein for consecutive three days before OVA excited the mice. This study at first demonstrated that the transplantation of TCs could improve allergen-induced asthma by obviously inhibiting airway inflammation and airway hyper-responsiveness preclinically, with the do

SUBMITTER: Ye L 

PROVIDER: S-EPMC5661110 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature