Age-dependent alterations in osteoblast and osteoclast activity in human cancellous bone.

ABSTRACT: It is assumed that the activity of osteoblasts and osteoclasts is decreased in bone tissue of aged individuals. However, detailed investigation of the molecular signature of human bone from young compared to aged individuals confirming this assumption is lacking. In this study, quantitative expression analysis of genes related to osteogenesis and osteoclastogenesis of human cancellous bone derived from the distal radius of young and aged individuals was performed. Furthermore, we additionally performed immunohistochemical stainings. The young group included 24 individuals with an average age of 23.2 years, which was compared to cancellous bone derived from 11 body donators with an average age of 81.0 years. In cancellous bone of young individuals, the osteogenesis-related genes RUNX-2, OST

SUBMITTER: Becerikli M 

PROVIDER: S-EPMC5661248 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature