Let's talk about Secs: Sec61, Sec62 and Sec63 in signal transduction, oncology and personalized medicine.

ABSTRACT: The heterotrimeric Sec61 complex and the dimeric Sec62/Sec63 complex are located in the membrane of the human endoplasmic reticulum (ER) and play a central role in translocation of nascent and newly synthesized precursor polypeptides into the ER. This process involves targeting of the precursors to the membrane and opening of the polypeptide conducting Sec61 channel for translocation. Apart from this central role in the intracellular transport of polypeptides, several studies of the last decade uncovered additional functions of Sec proteins in intracellular signaling: Sec62 can induce ER-phagy in the process of recovery of cells from ER stress and the Sec61 channel can also act as a passive ER calcium leak channel. Furthermore, mutations, amplifications and an overexpression of the SEC<

SUBMITTER: Linxweiler M 

PROVIDER: S-EPMC5661625 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature