Thin endometrium transcriptome analysis reveals a potential mechanism of implantation failure.

ABSTRACT:

Aim

Although a thin endometrium has been well recognized as a critical factor in implantation failure, little information is available regarding the molecular mechanisms. The present study investigated these mechanisms by using genome-wide mRNA expression analysis.

Methods

Thin and normal endometrial tissue was obtained from a total of six women during the mid-luteal phase of the menstrual cycle. The transcriptomes were analyzed with a microarray. Differentially expressed genes were classified according to Gene Ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways.

Results

The study identified 318 up-regulated genes and 322 down-regulated genes in the thin endometrium, compared to the control endometrium. The GO and KEGG pathway analyses indi

SUBMITTER: Maekawa R 

PROVIDER: S-EPMC5661823 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature