Imaging of Integrin α_vβ₃ Expression in Lung Cancers and Brain Tumors Using Single-Photon Emission Computed Tomography with a Novel Radiotracer ^99mTc-IDA-D-[c(RGDfK)]₂.

ABSTRACT: Integrin α_vβ₃ is a molecular marker for the estimation of tumor angiogenesis and is an imaging target for radiolabeled Arg-Gly-Asp (RGD) peptides. In this study, the authors investigated the clinical efficacy and safety of a novel radiolabeled RGD peptide, ^99mTc-IDA-D-[c(RGDfK)]₂, for the imaging of integrin α_vβ₃ expression, as a measure of tumor angiogenesis in lung cancers and brain tumors. Five patients with lung cancers and seven with brain tumors underwent ^99mTc-IDA-D-[c(RGDfK)]₂ single-photon emission computed tomography (SPECT) imaging. Tumors were also assessed using ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography. Uptake of the radiotracer was expressed as the

SUBMITTER: Song YS 

PROVIDER: S-EPMC5661893 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature