Comparison of two control groups for estimation of oral cholera vaccine effectiveness using a case-control study design.

ABSTRACT:

Background

Case-control studies to quantify oral cholera vaccine effectiveness (VE) often rely on neighbors without diarrhea as community controls. Test-negative controls can be easily recruited and may minimize bias due to differential health-seeking behavior and recall. We compared VE estimates derived from community and test-negative controls and conducted bias-indicator analyses to assess potential bias with community controls.

Methods

From October 2012 through November 2016, patients with acute watery diarrhea were recruited from cholera treatment centers in rural Haiti. Cholera cases had a positive stool culture. Non-cholera diarrhea cases (test-negative controls and non-cholera diarrhea cases for bias-indicator analyses) had a negative culture and rapid test. Up to fo

SUBMITTER: Franke MF 

PROVIDER: S-EPMC5661944 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature