Ontology highlight
ABSTRACT:
SUBMITTER: Jiang S
PROVIDER: S-EPMC5662195 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Cell host & microbe 20171001 4
Epstein-Barr virus (EBV) transforms B cells to continuously proliferating lymphoblastoid cell lines (LCLs), which represent an experimental model for EBV-associated cancers. EBV nuclear antigens (EBNAs) and LMP1 are EBV transcriptional regulators that are essential for LCL establishment, proliferation, and survival. Starting with the 3D genome organization map of LCL, we constructed a comprehensive EBV regulome encompassing 1,992 viral/cellular genes and enhancers. Approximately 30% of genes ess ...[more]