Percutaneous coronary intervention versus cardiac bypass surgery for left main coronary artery disease: A trial sequential analysis.

ABSTRACT:

Background

Several updated meta-analyses comparing percutaneous coronary intervention (PCI) with coronary artery bypass grafting (CABG) for left main coronary artery disease (LM CAD) have been published recently. However, the risk of false-positive results could be high in conventional updated meta-analyses due to repetitive testing of accumulating data. Therefore, we compared these treatment approaches via trial sequential analysis (TSA).

Methods

The MEDLINE, Embase, and Cochrane Central Register of Controlled Trials databases were searched for published randomized controlled trials (RCTs) or subgroups of RCTs comparing PCI and CABG in patients with LM CAD. The primary outcome was major cardiac and cerebrovascular adverse events (MACCE). TSA was used to confirm the conclusi

SUBMITTER: Ye Y 

PROVIDER: S-EPMC5662302 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature