Action Potential Shortening and Impairment of Cardiac Function by Ablation of Slc26a6.

ABSTRACT:

Background

Intracellular pH (pH_i) is critical to cardiac excitation and contraction; uncompensated changes in pH_i impair cardiac function and trigger arrhythmia. Several ion transporters participate in cardiac pH_i regulation. Our previous studies identified several isoforms of a solute carrier Slc26a6 to be highly expressed in cardiomyocytes. We show that Slc26a6 mediates electrogenic Cl^-/HCO₃^- exchange activities in cardiomyocytes, suggesting the potential role of Slc26a6 in regulation of not only pH_i, but also cardiac excitability.

Methods and results

To test the mechanistic role of Slc26a6 in the heart, we took advantage of Slc26a6 knockout (Slc26a6^-/-<

SUBMITTER: Sirish P 

PROVIDER: S-EPMC5662469 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature