Polyclonal Regulatory T Cell Therapy for Control of Inflammation in Kidney Transplants.

ABSTRACT: Early subclinical inflammation in kidney transplants is associated with later graft fibrosis and dysfunction. Regulatory T cells (Tregs) can reverse established inflammation in animal models. We conducted a pilot safety and feasibility trial of autologous Treg cell therapy in three kidney transplant recipients with subclinical inflammation noted on 6-month surveillance biopsies. Tregs were purified from peripheral blood and polyclonally expanded ex vivo using medium containing deuterated glucose to label the cells. All patients received a single infusion of ~320 × 10⁶ (319, 321, and 363.8 × 10⁶ ) expanded Tregs. Persistence of the infused Tregs was tracked. Graft inflammation was monitored with follow-up biopsies and urinary biomarkers. Nearly 1 × 10⁹ (0.93

SUBMITTER: Chandran S 

PROVIDER: S-EPMC5662482 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature