Relationship between white matter connectivity loss and cortical thinning in cerebral amyloid angiopathy.

ABSTRACT: Patients with cerebral amyloid angiopathy (CAA) show loss of white matter connectivity and cortical thinning on MRI, primarily in posterior brain regions. Here we examined whether a potential causal relationship exists between these markers of subcortical and cortical brain injury by examining whether changes in cortical thickness progress in tandem with changes in their underlying connections. Thirty-one patients with probable CAA with brain MRI at two time points were included (follow-up time: 1.3 ± 0.4 years). Brain networks were reconstructed using diffusion MRI-based fiber tractography. Of each network node, we calculated the change in fractional anisotropy-weighted connectivity strength over time and the change in cortical thickness. The association between change in connectivity str

SUBMITTER: Reijmer YD 

PROVIDER: S-EPMC5662494 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature