An automated platform for high-throughput mouse behavior and physiology with voluntary head-fixation.

ABSTRACT: Recording neural activity during animal behavior is a cornerstone of modern brain research. However, integration of cutting-edge technologies for neural circuit analysis with complex behavioral measurements poses a severe experimental bottleneck for researchers. Critical problems include a lack of standardization for psychometric and neurometric integration, and lack of tools that can generate large, sharable data sets for the research community in a time and cost effective way. Here, we introduce a novel mouse behavioral learning platform featuring voluntary head fixation and automated high-throughput data collection for integrating complex behavioral assays with virtually any physiological device. We provide experimental validation by demonstrating behavioral training of mice in visual d

SUBMITTER: Aoki R 

PROVIDER: S-EPMC5662625 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature