An Effective Model of the Retinoic Acid Induced HL-60 Differentiation Program.

ABSTRACT: In this study, we present an effective model All-Trans Retinoic Acid (ATRA)-induced differentiation of HL-60 cells. The model describes reinforcing feedback between an ATRA-inducible signalsome complex involving many proteins including Vav1, a guanine nucleotide exchange factor, and the activation of the mitogen activated protein kinase (MAPK) cascade. We decomposed the effective model into three modules; a signal initiation module that sensed and transformed an ATRA signal into program activation signals; a signal integration module that controlled the expression of upstream transcription factors; and a phenotype module which encoded the expression of functional differentiation markers from the ATRA-inducible transcription factors. We identified an ensemble of effective model parameters u

SUBMITTER: Tasseff R 

PROVIDER: S-EPMC5662654 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature