Primary tumor resection in stage IV unresectable colorectal cancer: what has changed?

ABSTRACT: Most current guidelines do not recommend primary tumor resection in stage IV unresectable colorectal cancer. Rapid chemotherapy development over the last decade has substantially changed the decision making. However, results of recently published trials and meta-analyses suggest that primary tumor resection may in fact be beneficial, principally in terms of prolonged survival. Additional factors, such as use of minimally invasive approach or protocols of enhanced recovery after surgery, affect clinical outcomes as well, but are often neglected when discussing the state of the art in this area. There are still no randomized studies determining the legitimacy of upfront surgery in asymptomatic patients. Also, quality of life also plays an important role in choosing appropriate treatment. Hav

SUBMITTER: Pedziwiatr M 

PROVIDER: S-EPMC5662673 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature