Quantification of Tau Load Using [¹⁸F]AV1451 PET.

ABSTRACT:

Purpose

The tau tracer [¹⁸F]AV1451, also known as flortaucipir, is a promising ligand for imaging tau accumulation in Alzheimer's disease (AD). Most of the previous studies have quantified tau load using standardized uptake value ratios (SUVr) derived from a static [¹⁸F]AV1451 scan. SUVr may, however, be flow dependent and, especially for longitudinal studies, should be validated against a fully quantitative approach. The objective of this study was to identify the optimal tracer kinetic model for measuring tau load using [¹⁸F]AV1451.

Procedures

Following intravenous injection of 225 ± 16 MBq [¹⁸F]AV1451, 130 min dynamic PET scans were performed in five biomarker confirmed AD patients and five controls. Arterial blood sampling was

SUBMITTER: Golla SSV 

PROVIDER: S-EPMC5662681 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature